25 March 2015
Phase 3 STAND Trial Launches to Advance PaMZ through Final Stage of Testing
PRETORIA - A new tuberculosis (TB) drug regimen designed to improve options for TB therapy eliminated more bacteria from sputum than standard therapy and did so at a faster rate, according to data from a phase 2b clinical trial published today in The Lancet. These results are published just as the global phase 3 clinical trial, designed to bring this regimen through the last stage of testing, has begun.
PaMZ is a three-drug regimen comprised of two candidate drugs that are not yet licensed for use against TB: pretomanid (Pa), formerly known as PA-824, and moxifloxacin (M), and one antibiotic, pyrazinamide (Z), which is approved for use in TB treatment today. The therapy is intended for those patients whose TB infections are sensitive to the three drugs, including people with drug-sensitive and multidrug-resistant TB (MDR-TB).